Importance of endocrine treatment adherence and persistence in breast cancer survivorship: a systematic review
Importance of endocrine treatment adherence and persistence in breast cancer survivorship: a systematic review
Blog Article
Abstract Purpose Adjuvant endocrine treatment is essential for treating luminal subtypes of breast cancer, which constitute 75% of all breast malignancies.However, the detrimental side effects of treatment make it difficult for many patients to complete the guideline-required treatment.Such non-adherence may jeopardize the lifesaving ability of anti-estrogen therapy.In this systematic review, we aimed to assess the consequences of non-adherence and non-persistence from available studies meeting strict statistical and clinical criteria.Methods A systematic literature search was performed using several databases, yielding identification of 2,026 studies.
After strict selection, 14 studies were eligible lovesense 3 for systematic review.The review included studies that examined endocrine treatment non-adherence (patients not taking treatment as prescribed) or non-persistence (patients stopping treatment prematurely), in terms of the effects on event-free survival or overall survival among women with non-metastatic breast cancer.Results We identified 10 studies measuring the effects of endocrine treatment non-adherence and non-persistence on event-free survival.Of these studies, seven showed significantly poorer survival for the non-adherent or non-persistent patient groups, with hazard ratios (HRs) ranging from 1.39 (95% CI, 1.
07 to 1.53) to 2.44 (95% CI, 1.89 to 3.14).
We identified nine studies measuring the effects of endocrine treatment non-adherence and non-persistence on overall survival.Of these studies, seven demonstrated significantly reduced overall survival in the here groups with non-adherence and non-persistence, with HRs ranging from 1.26 (95% CI, 1.11 to 1.43) to 2.
18 (95% CI, 1.99 to 2.39).Conclusion The present systematic review demonstrates that non-adherence and non-persistence to endocrine treatment negatively affect event-free and overall survival.Improved follow-up, with focus on adherence and persistence, is vital for improving health outcomes among patients with non-metastatic breast cancer.